Cellular senescence: implications for cancer therapy
Auteur :
Mirzayans, Razmik / Murray, David
Éditeur :
Nova Science Publishers Inc
ISBN :
9781606926765
Date de publication :
5 mai 2009
Dimensions :
15,5 x 23,0 cm
Poids :
224 g
Langue :
Anglais
Pays d'origine :
USA
Offers evidence reinforcing the notion that ionising radiation-triggered premature senescence in cancer cells is generally dependent on the wild-type p53 function, and that the development of giant cells is a response of p53-deficient cells, presumably reflecting their failure to engage the premature senescence program.