Noninferiority testing in clinical trials: issues and challenges
Auteur :
Ng, Tie-Hua
Éditeur :
Taylor & Francis Ltd
ISBN :
9780367576028
Date de publication :
30 juin 2020
Dimensions :
23,4 x 15,6 cm
Poids :
380 g
Langue :
Anglais
Pays d'origine :
Grande Bretagne
Requiring no prior knowledge of NI testing, this book explains how to choose the NI margin as a small fraction of the therapeutic effect of the active control in a clinical trial. It discusses issues with estimating the effect size based on historical placebo control trials of the active control. The author covers basic concepts related to NI tr