Development of mirror-image vhhs with less immunogenicity
Auteur :
Aoki, Keisuke
Éditeur :
Springer Nature Switzerland AG
ISBN :
9789819613007
Date de publication :
14 janv. 2025
Dimensions :
23,5 x 15,5 cm
Langue :
Anglais
Pays d'origine :
Suisse
This book outlines the chemical synthesis of therapeutic targets and a screening process for unexplored mirror-image single-domain antibodies (D-VHH). This book first describes the chemical synthesis of model VHH and the characteristics of both enantiomeric VHHs, including binding activity, biodistribution and immunogenicity.